THIS INFORMATION IS INTENDED FOR US HEALTHCARE PROFESSIONALS
ABOUT CUMBERLAND  |  IMPORTANT SAFETY INFORMATION  |  FULL PRESCRIBING INFORMATION
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Mechanism of Action

Targets AVP and excess water to raise serum sodium concentration1,2

In patients with hyponatremia, the neurohormone arginine vasopressin (AVP) binds to the V2 receptors in the collecting ducts of the kidneys, resulting in free water reabsorption.3-5

  • Vaprisol is an aquaretic2
  • By blocking AVP at the V2 receptor, Vaprisol promotes free water clearance and raises serum sodium concentration to regulate the water/sodium balance1

This video brings the role of AVP in hyponatremia to life:

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REFERENCES: 1. Vaprisol Prescribing Information. Cumberland Pharmaceuticals Inc. 2. Verbalis JG, Goldsmith SR, Greenberg A, Schrier RW, Sterns RH. Hyponatremia treatment guidelines 2007: expert panel recommendations. Am J Med. 2007;120(11A):S1-S21. 3. Verbalis JG. Disorders of body water homeostasis. Best Pract Res Clin Endocrinol Metab. 2003;17:471-503. 4. Janicic N, Verbalis JG. Evaluation and management of hypo-osmolality in hospitalized patients. Endocrinol Metab Clin North Am. 2003;32:459-481. 5. Tahara A, Tomura Y, Wada K-I, et al. Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther. 1997;282:301-308.